Clinical trials.
RVS of CNY participates in industry-sponsored and investigator-initiated clinical trials in retinal disease. Below are our currently enrolling and upcoming studies. To inquire about eligibility, ask your referring physician or contact our research coordinator. We keep this page as up to date as possible, but trial status can change quickly — please call to confirm before referring or planning a visit.
Currently enrolling
Updated as frequently as possible
TRL-01
CapriDiabetic Macular Edema
EYP Insert versus Eylea for diabetic macular edema. 88-week study.
Enrolling
TRL-02
4D-4FRONTWet AMD
4D-150 gene therapy versus standard Eylea injections for wet AMD. Two-year study.
Enrolling
TRL-03
AquariusWet AMD
Ixo-vec gene therapy versus Eylea for wet AMD. Five-year study. Enrollment closes August 14, 2026 — the study continues for participants already enrolled.
Enrolling until 8/14
TRL-04
MalbecWet AMD
MK-8748, an investigational bispecific Tie2 activator and VEGF inhibitor, versus standard Eylea injections for wet AMD. Roughly two-year study.
Enrolling
TRL-05
ABP938Wet AMD · Treatment-Naïve
ABP938, an investigational aflibercept 8 mg biosimilar, versus Eylea HD in treatment-naïve wet AMD. One-year study.
Enrolling
TRL-06
SiennaGeographic Atrophy
Subcutaneous pozelimab plus cemdisiran versus cemdisiran alone versus placebo for geographic atrophy secondary to AMD. Two-year study.
Enrolling
TRL-07
Galaxy ONLGeographic Atrophy · Non-Subfoveal
ONL 1204 versus Izervay versus sham for non-subfoveal geographic atrophy. 72-week study.
Enrolling
TRL-08
Astellas Real-WorldGeographic Atrophy · Izervay
Real-world observational study of Izervay (avacincaptad pegol) for geographic atrophy. Five-year study.
Enrolling
Upcoming
We are also planning future trials in geographic atrophy, wet AMD, retinal vein occlusion, and diabetic macular edema, with new studies expected to open over the coming months.
How to inquire about a trial
If you are a patient, the best path is to ask your referring eye doctor whether enrollment may be appropriate, or to bring it up at your next visit with us. If you are a physician interested in referring for a specific trial, please contact our research coordinator at (315) 445-8166.
